top of page
This site was designed with the
.com
website builder. Create your website today.Start Now

John Adams

 

Dr. Adams is a malaria researcher in USF’s College of Public Health. Broadly, his research focuses on host-parasite interactions and improving the understanding of processes critical for infection and pathogenesis in Plasmodium falciparum and Plasmodium vivax. More specifically, his lab uses genomic studies to better understand key parasite processes and targets. A large scale transposon mutagenesis screen uses whole genome piggyBac insertional mutagenesis of P. falciparum to experimentally identify and validate critical processes and pathways that are novel antimalarial drug targets. Chemogenetic profiling is used to define critical pathways linked to Artemisinin resistance, understand the mechanism of action of antimalarial drugs, and predict optimal drug combination therapies. Additionally, his lab uses functional genomic studies to identify essential genes of P. falciparum through whole genomic piggyBac mutagenesis and genotype-phenotype associations using forward genetic screens

​

 

 

Publications

 

  • Bronner IF, Otto TD, Zhang M, Udenze K, Wang C, Quail MA, Jiang RHY, Adams JH, Rayner JC. 2016. Quantitative insertion-site sequencing (QIseq) for high throughput phenotyping of transposon mutants. Genome Res 26:980–9.

  •  

  • Chen E, Salinas ND, Huang Y, Ntumngia F, Plasencia MD, Gross ML, Adams JH, Tolia NH. 2016. Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein. Proc Natl Acad Sci U S A 113:6277–82.

  •  

  • Pradhan A, Siwo GH, Singh N, Martens B, Balu B, Button-Simons KA, Tan A, Zhang M, Udenze KO, Jiang RHY, Ferdig MT, Adams JH, Kyle DE. 2015. Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery. Sci Rep 5:15930.

  •  

  • Mikolajczak SA, Vaughan AM, Kangwanrangsan N, Roobsoong W, Fishbaugher M, Yimamnuaychok N, Rezakhani N, Lakshmanan V, Singh N, Kaushansky A, Camargo N, Baldwin M, Lindner SE, Adams JH, Sattabongkot J, Prachumsri J, Kappe SHI. 2015. Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice. Cell Host Microbe 17:526–35.

  •  

  • Lupton EJ, Roth A, Patrapuvich R, Maher SP, Singh N, Sattabongkot J, Adams JH. 2015. Enhancing longevity of Plasmodium vivax and P. falciparum sporozoites after dissection from mosquito salivary glands. Parasitol Int 64:211–218.

  •  

  • Chootong P, McHenry AM, Ntumngia FB, Sattabongkot J, Adams JH. 2014. The association of Duffy binding protein region II polymorphisms and its antigenicity in Plasmodium vivax isolates from Thailand. Parasitol Int 63:858–64.

  •  

  • Souza-Silva FA, Torres LM, Santos-Alves JR, Tang ML, Sanchez BAM, Sousa TN, Fontes CJF, Nogueira PA, Rocha RS, Brito CFA, Adams JH, Kano FS, Carvalho LH. 2014. Duffy antigen receptor for chemokine (DARC) polymorphisms and its involvement in acquisition of inhibitory anti-duffy binding protein II (DBPII) immunity. PLoS One 9:e93782.

  •  

  • Campbell CO, Santiago DN, Guida WC, Manetsch R, Adams JH. 2014. In silico characterization of an atypical MAPK phosphatase of Plasmodium falciparum as a suitable target for drug discovery. Chem Biol Drug Des 84:158–68.

  •  

  • Ntumngia FB, Schloegel J, McHenry AM, Barnes SJ, George MT, Kennedy S, Adams JH. 2013. Immunogenicity of single versus mixed allele vaccines of Plasmodium vivax Duffy binding protein region II. Vaccine 31:4382–8.

  •  

  • Handa S, Ramamoorthy D, Spradling TJ, Guida WC, Adams JH, Bendinskas KG, Merkler DJ. 2013. Production of recombinant 1-deoxy-d-xylulose-5-phosphate synthase from Plasmodium vivax in Escherichia coli. FEBS Open Bio 3:124–9.

  •  

  • Auliff AM, Balu B, Chen N, O’Neil MT, Cheng Q, Adams JH. 2012. Functional analysis of Plasmodium vivax dihydrofolate reductase-thymidylate synthase genes through stable transformation of Plasmodium falciparum. PLoS One 7:e40416.

  •  

  • Ntumngia FB, Schloegel J, Barnes SJ, McHenry AM, Singh S, King CL, Adams JH. 2012. Conserved and variant epitopes of Plasmodium vivax Duffy binding protein as targets of inhibitory monoclonal antibodies. Infect Immun 80:1203–8.

  •  

  • King CL, Adams JH, Xianli J, Grimberg BT, McHenry AM, Greenberg LJ, Siddiqui A, Howes RE, da Silva-Nunes M, Ferreira MU, Zimmerman PA. 2011. Fy(a)/Fy(b) antigen polymorphism in human erythrocyte Duffy antigen affects susceptibility to Plasmodium vivax malaria. Proc Natl Acad Sci U S A 108:20113–8.

  •  

  • Balu B, Maher SP, Pance A, Chauhan C, Naumov A V, Andrews RM, Ellis PD, Khan SM, Lin J-W, Janse CJ, Rayner JC, Adams JH. 2011. CCR4-associated factor 1 coordinates the expression of Plasmodium falciparum egress and invasion proteins. Eukaryot Cell 10:1257–63.

  •  

  • Fonager J, Franke-Fayard BMD, Adams JH, Ramesar J, Klop O, Khan SM, Janse CJ, Waters AP. 2011. Development of the piggyBac transposable system for Plasmodium berghei and its application for random mutagenesis in malaria parasites. BMC Genomics 12:155.

bottom of page